Research Studies on Medicinal Use of Saffron

What is Saffron? Saffron is a spice derived from the stigma (the female reproductive part) of the Crocus sativus flower.    Saffron has been used in many cultures for medicinal purposes.  It has been used for thousands of years in some areas of the world.    Due to the long positive history of saffron, research studies have been done on Saffron.   While more research needs to be completed, the research is promising.   See some of the research studies below. 

  1. Depression and Mood Enhancement

Saffron has been traditionally used to improve mood and alleviate symptoms of mild to moderate depression. Some studies suggest that saffron may have mood-enhancing effects by influencing serotonin levels in the brain.

Reference: Akhondzadeh, S., Fallah-Pour, H., Afkham, K., Jamshidi, A. H., & Khalighi-Cigaroudi, F. (2004). Comparison of Crocus sativus L. and imipramine in the treatment of mild to moderate depression: a pilot double-blind randomized trial. BMC Complementary and Alternative Medicine, 4, 12.

  • Pain Relief    Saffron may have analgesic properties and can help alleviate mild pain and discomfort. It has been used in traditional medicine for pain relief, particularly in conditions like headaches and menstrual cramps.

Reference: Agha‐Hosseini, M., Kashani, L., Aleyaseen, A., Ghoreishi, A., Rahmanpour, H., Zarrinara, A. R., … & Akhondzadeh, S. (2008). Crocus sativus L. (saffron) in the treatment of premenstrual syndrome: a double‐blind, randomised and placebo‐controlled trial. BJOG: An International Journal of Obstetrics & Gynaecology, 115(4), 515-519.

  • Weight Management:   Saffron may act as an appetite suppressant for some.  It may also act as a mood enhancer which can reduce binge eating or emotional eating for some.

Reference: Gout, B., Bourges, C., & Paineau-Dubreuil, S. (2010). Satiereal, a Crocus sativus L extract, reduces snacking and increases satiety in a randomized placebo-controlled study of mildly overweight, healthy women. Nutrition Research, 30(5), 305-313.

Caution:  Please note that while these studies suggest potential benefits of saffron for various health conditions, further research is needed to establish the full extent of its efficacy and safety, and it should be used under the guidance of a healthcare professional. Additionally, the effectiveness of saffron may vary depending on the preparation and dosage used.

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